We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. Enhancing Recovery After Surgery THEME 2: REMOTE MONITORING AND VIRTUAL CARE Date Alex Baron | January 2024 As we age it can take longer for our bodies to heal from trauma. As many as 40% of patients that undergo surgery will have major complications that lead to long-term health problems, such as heart disease or stroke. This is especially true for adults over the age of 65 following a major surgery, with many experiencing difficulties in returning to their pre-operation levels of function. Led by Dr. Duminda Wijeysundera, MD, at the University of Toronto, the Functional Improvement Trajectories After Surgery (FIT After Surgery) study aims to gain a better understanding of how often and why some patients experience significant disability after surgery. ​ As one of 14 study sites across Canada, W21C is currently working with the Calgary site lead, Dr. Melinda Davis, MD, director of Master Teaching Program, clinical associate professor, Cumming School of Medicine, on recruitment efforts at the Foothills Medical Centre, actively engaging with patients prior to their surgery. Patient recruitment for the Calgary site began in July 2021 and is ongoing. Researchers are excited about the possibilities this work could reveal, especially as Canada’s population continues to age and the likelihood of more seniors needing major surgery every year is increasing. ​ Having a better understanding of when and why patients experience disability after surgery will enable patients to make better-informed decisions about having surgery and allow physicians to identify patients that may need additional support following surgery. Overall recruitment and follow up for the study is expected to finish in 2023, with preliminary results anticipated in early 2024. ​ By capitalizing on W21C's capabilities in eHealth and mHealth technologies, fostering collaboration, and actively engaging communities, the Health Everywhere Hub is poised to play a pivotal role in improving seniors' recovery experiences post-major surgeries. Project Contact: Dr. Mary Brindle Image Sources: Adobe Stock

News UCalgary-based program expands province-wide in supporting digital health researchers Date We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. September 11, 2023 | Alex Baron, W21C Research and Innovation Centre For the first time, researchers in digital health from Alberta post-secondary institutions will all share access to expert support in translating research innovation into improved care for citizens through an expansion of the newly renamed SPARK Alberta program. The boost is thanks to a new grant from Alberta Innovates. Launched in 2020 as SPARK Calgary, the program has been providing expert advice, education and ecosystem connections for evidence-based digital health innovations in Calgary for the last three years. Based out of the University of Calgary’s W21C Research and Innovation Centre, the program recruited its fourth cohort in spring 2023 and has worked with more than 70 faculty and researchers supporting 14 projects. ​ The SPARK model originated from Stanford University in 2006 with the aim of advancing research discoveries from academia to the health-care system. Now a global network of more than 60 academic institutions across six continents, SPARK Alberta represents the only active SPARK site in Canada. ​ Earlier this year, SPARK Alberta was awarded a grant by Alberta Innovates’ Ecosystem Development Partnerships Program. With this grant, SPARK will leverage its previous success in Calgary and expand the program provincially, further establishing Alberta’s reputation as a province with strong digital health innovation. ​ “This grant will allow us to offer our resources and expertise to faculty and researchers developing innovations from post-secondary institutions from across the province,” says Dr. Scott Kraft, MD, director of SPARK Alberta and clinical associate professor in the Cumming School of Medicine (CSM). “Our aim is to form a central network, linking and co-ordinating digital health innovation across Alberta’s post-secondary institutions.” SPARK graduates have impact The Calgary Pediatric Brain-Computer Interface Program (BCI4Kids) plays a pivotal role in addressing the challenges currently faced by thousands of Canadian children with neurological disabilities. These disabilities often hinder their ability to fully engage in daily life and exercise their fundamental rights to interact with the world. ​ Operating out of the Alberta Children’s Hospital and affiliated with the CSM, the BCI4Kids program is led by Dr. Adam Kirton, MSc’96, MD, a CSM professor and technology solutions research lead for One Child Every Child, a UCalgary research initiative with a vision for all children to be healthy, empowered and thriving. BCI4Kids focuses on cutting-edge brain-computer interface (BCI) technology to provide children suffering from severe neurological disabilities with an avenue to achieve greater independence and an improved quality of life. ​ From the BCI4Kids program came a commercial venture called Possibility Neurotechnologies. Incorporated in October 2022, Possibility Neurotechnologies is dedicated to integrating BCI technology into everyday life, enabling those with severe physical disabilities to interact and communicate in transformative ways. In March 2023, the research team successfully graduated from the SPARK program. ​ Its flagship product, Think2Switch, allows individuals to control household electronic devices using only their thoughts. By creating user-friendly and accessible technology, the team aims to enhance independence and quality of life, making previously unimaginable interactions possible for those in need. ​ “Participating in the SPARK program has been an invaluable experience for Possibility Neurotechnologies,” says Dr. Dion Kelly, MBT’18, PhD’23, co-founder and CEO of Possibility Neurotechnologies and clinical neuroscientist at BCI4Kids. “The monthly check-ins served as crucial touchpoints, compelling us to regularly evaluate our progress and address setbacks head-on.” ​ Since joining the SPARK program, Possibility Neurotechnologies has achieved significant growth, including being accepted into the Remarkable Accelerator Program, receiving an equity investment from the Cerebral Palsy Alliance, and showcasing its Think2Switch technology at international events. With a growing mailing list and a lineup of prospective customers, the team is preparing for a limited market release in Q1 2024. Image Source: SPARK Team Project Contact- Alex Baron, W21C Research and Innovation Centre

News Health Everywhere Launch Event Date We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. March 6, 2024 | Alex Baron On January 23, 2024, over 100 guests joined us as we held the Dr. Mamoru ‘Mo’ Watanabe Lectureship on Digital Health Today and Tomorrow. Hosted by the W21C Research and Innovation Centre, this event formally introduced and showcased "Health Everywhere", a new eHealth and mHealth hub created from a $6.3M Major Innovation Fund award from the Government of Alberta. This lectureship series honours the contributions of Dr. Mamoru ‘Mo’ Watanabe. Joining the University of Calgary’s Faculty of Medicine (now named Cumming School of Medicine) to serve as professor and head of internal medicine in 1974, Dr. Watanabe served as dean of the Faculty of Medicine from July 1982 until June 1992, and is believed to be the first Japanese Canadian dean of a Canadian medical school. He passed away July 5, 2023, at the age of 90. Opening remarks were provided by Dr. Mary Brindle, W21C Academic Director, and Dr. William Ghali, Vice-President (Research) at the University of Calgary. Dr. Ghali shared with the audience his memories of working with Dr. Watanabe and his legacy in digital health. The event was then led in a keynote address by Dr. James A. Makokis, speaking on the negative role colonialism continues to play in healthcare for Indigenous Canadians. This was followed by a lecture from Dr. Christy Cauley on the integration of mobile health to optimize recovery in patients. After a quick intermission the audience was introduced to Health Everywhere by five of its lead researchers. This included presentations from Dr. Chad Saunders, Dr. Martin Ferguson-Pell, Dr. Mary Brindle, Dr. Matt James, and Dr. Tyler Williamson. These presentations were followed by a Q&A with all the leads participating at once. Overall, the three-hour event proved to be a wonderful opportunity for the Health Everywhere team to introduce this initiative to the public while also making great connections between industry and academic leaders. ​ ​ Image Source: Brittany DeAngelis, O’Brien Institute for Public Health Project Contact- Alex Baron

We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. THEME 1: BRIDGING COMMUNITY AND ACUTE CARE Date Advancing eHealth Innovation to Enable Intelligent Patient Monitoring January 2024 Prevention of pressure injuries (PIs) is a priority for healthcare systems worldwide. Also referred to as pressure ulcers or bedsores, this condition is a skin and soft tissue injury that forms because of constant or prolonged pressure on the skin, typically occurring at bony areas on the body. Most prevalent in healthcare settings where the patient is unable to move frequently enough to relieve the pressure, PIs are painful for the patient and can lead to a deterioration in health, increased hospital stays, and even death. ​ To address this issue, W21C partnered with XSENSOR Technology Corporation, a Calgary-based company that designs, manufactures, and sells advanced pressure-imaging systems for use in medical environments worldwide. With support from W21C’s research team, this led to the creation of a novel pressure sensing device - the ForeSite PT™ System. In late 2007, an opportunity arose for W21C to partner with XSENSOR in the development and testing of a health innovation. The main objectives of this initiative were to better understand the potential of innovative technology to support healthcare providers in caring for patients at risk of pressure injuries. ​ W21C’s initial role was to collect and analyze focus group feedback from physicians, nurses, nursing assistants, occupational therapists, physiotherapists, and pressure mapping experts. Over time this progressed to usability testing of a protype device in a simulated Intensive Care Unit. Each phase of W21C research was followed by a design cycle at XSENSOR that consisted of research on every aspect of the system, including overall architecture, transducer design, sensing electronics, software, mechanical design, and packaging. ​ Through funding provided by Alberta Innovates ‘Accelerating Innovations into Care’ program, XSENSOR once again, approached W21C in 2023 to support the evaluation and impact on workflow of an updated system (referred to as ForeSite IS) in acute and long-term care, and to evaluate the device’s ability to predict skin breakdown of patients at elevated risk of PIs. This study is currently under way at Foothills Medical Centre and throughout several long-term care sites in the Calgary area. ​ To learn more about this project and its commercial capabilities, please visit XSENSOR’s website . Image Sources: Adobe Stock (top), XSENSOR.com (middle) Alex Baron

We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. UCalgary-based program expands province-wide in supporting digital health researchers NEWS Date Alex Baron, W21C Research and Innovation Centre | Sept 11, 2023 Project Contact: Image Source: iStock SPARK program receives grant from Alberta Innovates, supporting post-secondary innovators across Alberta in transforming ideas into clinical practice For the first time, researchers in digital health from Alberta post-secondary institutions will all share access to expert support in translating research innovation into improved care for citizens through an expansion of the newly renamed SPARK Alberta program. The boost is thanks to a new grant from Alberta Innovates . Launched in 2020 as SPARK Calgary, the program has been providing expert advice, education and ecosystem connections for evidence-based digital health innovations in Calgary for the last three years. Based out of the University of Calgary’s W21C Research and Innovation Centre , the program recruited its fourth cohort in spring 2023 and has worked with more than 70 faculty and researchers supporting 14 projects. ​ The SPARK model originated from Stanford University in 2006 with the aim of advancing research discoveries from academia to the health-care system. Now a global network of more than 60 academic institutions across six continents, SPARK Alberta represents the only active SPARK site in Canada. ​ Earlier this year, SPARK Alberta was awarded a grant by Alberta Innovates’ Ecosystem Development Partnerships Program . With this grant, SPARK will leverage its previous success in Calgary and expand the program provincially, further establishing Alberta’s reputation as a province with strong digital health innovation. ​ “This grant will allow us to offer our resources and expertise to faculty and researchers developing innovations from post-secondary institutions from across the province,” says Dr. Scott Kraft, MD, director of SPARK Alberta and clinical associate professor in the Cumming School of Medicine (CSM). “Our aim is to form a central network, linking and co-ordinating digital health innovation across Alberta’s post-secondary institutions.” BCI4Kids and Possibility Neurotechnologies team members, from left: Erica Floreani, Eli Kinney-Lang and Dion Kelly, present the Think2Switch. Dion Kelly is a clinical neuroscientist in the BCI4Kids Research Program. Credit: Dion Kelly SPARK graduates have impact ​ The Calgary Pediatric Brain-Computer Interface Program (BCI4Kids) plays a pivotal role in addressing the challenges currently faced by thousands of Canadian children with neurological disabilities. These disabilities often hinder their ability to fully engage in daily life and exercise their fundamental rights to interact with the world. ​ Operating out of the Alberta Children’s Hospital and affiliated with the CSM, the BCI4Kids program is led by Dr. Adam Kirton, MSc’96, MD, a CSM professor and technology solutions research lead for One Child Every Child , a UCalgary research initiative with a vision for all children to be healthy, empowered and thriving. BCI4Kids focuses on cutting-edge brain-computer interface (BCI) technology to provide children suffering from severe neurological disabilities with an avenue to achieve greater independence and an improved quality of life. ​ From the BCI4Kids program came a commercial venture called Possibility Neurotechnologies . Incorporated in October 2022, Possibility Neurotechnologies is dedicated to integrating BCI technology into everyday life, enabling those with severe physical disabilities to interact and communicate in transformative ways. In March 2023, the research team successfully graduated from the SPARK program. ​ Its flagship product, Think2Switch, allows individuals to control household electronic devices using only their thoughts. By creating user-friendly and accessible technology, the team aims to enhance independence and quality of life, making previously unimaginable interactions possible for those in need. ​ “Participating in the SPARK program has been an invaluable experience for Possibility Neurotechnologies, ” says Dr. Dion Kelly, MBT’18, PhD’23, co-founder and CEO of Possibility Neurotechnologies and clinical neuroscientist at BCI4Kids. “The monthly check-ins served as crucial touchpoints, compelling us to regularly evaluate our progress and address setbacks head-on .” ​ Since joining the SPARK program, Possibility Neurotechnologies has achieved significant growth, including being accepted into the Remarkable Accelerator Program, receiving an equity investment from the Cerebral Palsy Alliance, and showcasing its Think2Switch technology at international events. With a growing mailing list and a lineup of prospective customers, the team is preparing for a limited market release in Q1 2024. The SPARK Alberta program is managed by Nicola Quiggin and directed by Scott Kraft. Scott Kraft is a clinical associate professor in the Department of Clinical Neurosciences and director of SPARK Alberta. Credit: Nicola Quiggin Next steps for SPARK Alberta One of the goals of the SPARK Alberta program is to create a community focused on supporting Alberta-made digital health innovations. By joining SPARK, participating teams are making meaningful connections with others in this community. ​ “The in-person presentations and events fostered a dynamic network with other startups in the digital health ecosystem ,” says Dion. “Engaging with peers at various stages of development has enriched our journey, providing insights and camaraderie as we navigate the multifaceted process of growth and innovation. ” ​ Applications for the next cohort are open until Sept. 13. If you are a faculty member or researcher developing an evidence-based digital health innovation, visit the SPARK Alberta webpage to learn more about the program and to apply.

Dr. Martin Ferguson-Pell, a distinguished biomedical engineer and former Dean of the Faculty of Rehabilitation Medicine at the University of Alberta, is a leader in the field of rehabilitation and biomedical research. As the co-director of the University of Alberta's Rehabilitation Robotics Laboratory and a Principal Investigator in the Smart Network, he spearheads the development of virtual reality systems for healthcare learning objects and biomechanics research. Beyond academia, he played a pivotal role in establishing the Peter Lougheed Leadership College and actively supports leadership skills and mentorship for students. Serving as the CEO of the Alberta Bone and Joint Health Institute, Dr. Ferguson-Pell utilizes clinical data to drive innovations in bone and joint health, collaborating with the Bone and Joint Health Strategic Clinical Network. His extensive credentials include being a Fellow of Rehabilitation Engineering Society of America, a Chartered Physicist, a Certified Clinical Scientist, and a Fellow of the Royal Society of Arts. Notably, he co-founded Click&Push Accessibility Inc., a startup addressing barriers for individuals with mobility limitations, exemplifying his commitment to advancing accessibility and inclusivity. Remote Monitoring and Virtual Care Lead Martin Ferguson-Pell  fe4@ualberta.ca NEXT THEME LEAD

We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. 3 UCalgary projects receive $20.3M in provincial innovation grants NEWS Date Pamela Hyde, Office of the Vice-President (Research) | Sept 6, 2023 Project Contact: Image Source: iStock UCalgary’s innovation ecosystem just received a $20.3-million boost, thanks to Alberta’s Major Innovation Fund (MIF). On Sept. 5, Nate Glubish, minister of technology and innovation, announced that three UCalgary projects have received four years of funding to lead province-wide strategic initiatives to accelerate research and commercialization in the areas of medical devices, electronic and mobile health, and space and defence technologies. ​ “Provincial support for high-tech research and innovation will help our post-secondary scholars move from groundbreaking technological ideas to entrepreneurial realities, fuelling a more diverse economy and making a positive impact in the wider community ,” says Dr. Ed McCauley, president and vice-chancellor of the University of Calgary. ​ Major Innovation Fund projects are highly collaborative, requiring the engagement of scholars from institutions across Alberta, industry partners, and the communities that the projects intend to serve. It is an outcomes-focused program, funding projects that will attract and retain top talent, diversify Alberta’s economy, support industries and local businesses, and leverage additional investments. ​ “UCalgary’s innovation ecosystem is growing thanks to the drive of our research community and investments like the Major Innovation Fund ,” says Dr. William Ghali, vice-president (research). “These three projects will streamline the research-to-commercialization pipeline for their sector and create opportunities for both innovative research and widespread of adoption of novel, made-in-Alberta solutions .” UCalgary’s projects are the Alberta Medical Device Innovation Consortium, Health Everywhere, and Space and Defence Technologies Alberta. ​ ​ Health Everywhere ​ Lead investigator: Dr. Mary Brindle , MD, professor, Cumming School of Medicine ​ Alberta has pockets of excellence in eHealth (digital health technologies) and mHealth (mobile health technologies), which include novel programs and innovations. However, much of this excellence is disconnected and has tremendous untapped potential for collaboration and commercialization, and widespread adoption. ​ The vision of Health Everywhere is a vibrant eHealth and mHealth ecosystem in Alberta that builds on a foundation of strength in innovation to drive economic and technological growth. ​ “The rapid evolution of technology, the increasing complexity of medicine and the limitations of our current systems of patient care underscore the need for a human-centered approach to digital health ,” says Brindle. ​ “Health Everywhere will use digital-health technologies to allow patients to receive the best possible medical treatment whether it is in the hospital or in their own homes, and strengthen connections between care in the hospital and care in communities .” ​ Co-developed with community, industry, and academic stakeholders, Health Everywhere will be a provincial hub of digital health excellence that brings together integrated programs, leading experts, and resources to enable efficient and effective commercialization, spread, and scale of eHealth and mHealth technologies. ​ “The Health Everywhere program will create an ecosystem that puts exciting and impactful innovations in technology, computer science, and data analytics into the hands of teams who can use them to benefit the patients of today and tomorrow ,” says Brindle. ​ Health Everywhere is a UCalgary-led project, in partnership with the University of Alberta, Athabasca University, Lethbridge College, MacEwan University, Mount Royal University, NAIT, Red Deer Polytechnic and Southern Alberta Institute of Technology (SAIT).

We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. THEME 1: BRIDGING COMMUNITY AND ACUTE CARE Date Advancing eHealth Innovation to Enable Intelligent Patient Monitoring January 2024 Prevention of pressure injuries (PIs) is a priority for healthcare systems worldwide. Also referred to as pressure ulcers or bedsores, this condition is a skin and soft tissue injury that forms because of constant or prolonged pressure on the skin, typically occurring at bony areas on the body. Most prevalent in healthcare settings where the patient is unable to move frequently enough to relieve the pressure, PIs are painful for the patient and can lead to a deterioration in health, increased hospital stays, and even death. ​ To address this issue, W21C partnered with XSENSOR Technology Corporation, a Calgary-based company that designs, manufactures, and sells advanced pressure-imaging systems for use in medical environments worldwide. With support from W21C’s research team, this led to the creation of a novel pressure sensing device - the ForeSite PT™ System. In late 2007, an opportunity arose for W21C to partner with XSENSOR in the development and testing of a health innovation. The main objectives of this initiative were to better understand the potential of innovative technology to support healthcare providers in caring for patients at risk of pressure injuries. ​ W21C’s initial role was to collect and analyze focus group feedback from physicians, nurses, nursing assistants, occupational therapists, physiotherapists, and pressure mapping experts. Over time this progressed to usability testing of a protype device in a simulated Intensive Care Unit. Each phase of W21C research was followed by a design cycle at XSENSOR that consisted of research on every aspect of the system, including overall architecture, transducer design, sensing electronics, software, mechanical design, and packaging. ​ Through funding provided by Alberta Innovates ‘Accelerating Innovations into Care’ program, XSENSOR once again, approached W21C in 2023 to support the evaluation and impact on workflow of an updated system (referred to as ForeSite IS) in acute and long-term care, and to evaluate the device’s ability to predict skin breakdown of patients at elevated risk of PIs. This study is currently under way at Foothills Medical Centre and throughout several long-term care sites in the Calgary area. ​ To learn more about this project and its commercial capabilities, please visit XSENSOR’s website . Image Sources: Adobe Stock (top), XSENSOR.com (middle) Alex Baron, W21C Research and Innovation Centre

Theme 1: Bridging Community and Acute Care Advance eHealth Innovation to Enable Intelligent Patient Monitoring Date We envision a vibrant eHealth and mHealth ecosystem, accelerating innovation, growth, and transforming healthcare through collaboration and partnerships. January 5, 2024 | Dr. Jaime Kaufman Prevention of pressure injuries (PIs) is a priority for healthcare systems worldwide. Also referred to as pressure ulcers or bedsores, this condition is a skin and soft tissue injury that forms because of constant or prolonged pressure on the skin, typically occurring at bony areas on the body. Most prevalent in healthcare settings where the patient is unable to move frequently enough to relieve the pressure, PIs are painful for the patient and can lead to a deterioration in health, increased hospital stays, and even death. To address this issue, W21C partnered with XSENSOR Technology Corporation, a Calgary-based company that designs, manufactures, and sells advanced pressure-imaging systems for use in medical environments worldwide. With support from W21C’s research team, this led to the creation of a novel pressure sensing device - the ForeSite PT™ System. Image Sources: Adobe Stock (top), XSENSOR.com (middle) Project Contact- Dr. Jaime Kaufman

Dr. Matthew James is a distinguished specialist in Nephrology, holding the position of Associate Professor in the Departments of Medicine and Community Health Sciences at the University of Calgary. His research program is dedicated to patient-oriented research , with a specific focus on the development and implementation of risk prediction and clinical decision support tools aimed at enhancing the quality of care. Driven by a commitment to advancing healthcare, he also engages in pragmatic clinical trials centered around kidney and cardiovascular disease, contributing significantly to the ongoing evolution of medical practices in these critical areas. Bridging Community and Acute Care Lead Dr. Matthew James mjames@ucalgary.ca PREVIOUS THEME LEAD NEXT THEME LEAD